ca 4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T6212	Combretastatin A4	CA4,CRC 87-09	Microtubule Associated
	Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).		Microtubule Associated
T2782	Catharanthine	(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine	Calcium Channel , AChR
	Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).		Calcium Channel , AChR
T0916	Butamben	Butyl 4-aminobenzoate	Potassium Channel , Calcium Channel , Sodium Channel
	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.		Potassium Channel , Calcium Channel , Sodium Channel
T4284	Levamlodipine besylate	(S)-Amlodipine Besylate (103129-82-4(free base))	Calcium Channel
	Levamlodipine besylate ((S)-Amlodipine Besylate (103129-82-4(free base))) , also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipi...		Calcium Channel
T7334	NP118809	39-1B4	Calcium Channel
	NP118809 (39-1B4) is a potent N-type calcium channel blocker(IC50 : 0.11 μM).		Calcium Channel
T7550	Barnidipine	YM-09730-5(Free base),Mepirodipine	Calcium Channel
	Barnidipine (YM-09730-5(Free base)) is a calcium channel blocker.		Calcium Channel
T1606	Fasudil	HA-1077,AT877	ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
	Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T3060	Fasudil hydrochloride	Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
	Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T8590	4-(benzyloxy)benzene-1-sulfonamide		Others
	4-(benzyloxy)benzene-1-sulfonamide is inhibitor of human recombinant CA-7.		Others
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T35251	YK-5-252	YK 5 252,YK5-252,YK-5252
	YK-5-252 is a dual action combretastatin A-4 (CA-4) prodrug which releases CA-4 through a disulfide bond cleavage mechanism and contains a near-infrared (NIR) fluorophore.
T63276	HCAXII-IN-4
	hCAXII-IN-4 is a selective and potent CA XII inhibitor with a Ki value of 6.4 nM for human CA XII.
T16387	Ombrabulin	AVE8062,AC7700	Microtubule Associated
	Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.		Microtubule Associated
T82692	Comosone II
	Comosone II (Compound 4), a compound isolated from Curcuma zedoaria, exhibits moderate antiproliferative activity. For Ca Ski cancer cells, its IC50 value is 76 μg/mL, showing its inhibitory effect on cancer cell growth.
T31573	DPX-3778
	DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin ...
T16386	Ombrabulin hydrochloride	AVE8062 (hydrochloride),AC7700 (hydrochloride)	Microtubule Associated
	Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells and has antivascular effects. Ombrabulin is a tubulin polymeriz...		Microtubule Associated
T79195	Cav 3.2 inhibitor 4		Calcium Channel
	Cav 3.2 Inhibitor 4 (Compound 21) is a selective and potent inhibitor of the T-type calcium channel (Ca v 3.2), demonstrating peripheral restriction with an IC50 value of 0.6 μM. It is utilized in atrial fibrillation res...		Calcium Channel
T35713	N-desethyl Brinzolamide (oxalate)
	N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang...